Multiple brain abscesses due to Penicillium spp infection

Revista do Instituto de Medicina Tropical de São Paulo

Danilo Teixeira Noritomi²  Guilherme Linhares Bub²  Idal Beer²  Aloísio Souza Felipe Da Silva¹  Roberto De Cleva²  Joaquim José Gama-rodrigues² 

[1] ,University of São Paulo Medical School Hospital das Clínicas

关键词: Penicilliosis;    Penicillium spp;    CNS infection;    Fungal infection;   

DOI  :  10.1590/S0036-46652005000300010

来源: SciELO

【 摘 要 】

We present a case of central nervous system (CNS) infection by a member of the Penicillium genera in a HIV-negative man in Brazil. The patient was admitted complaining of loss of visual fields and speech disturbances. CT scan revealed multiple brain abscesses. Stereothacic biopsies revealed fungal infection and amphotericin B treatment begun with initial improvement. The patient died few days later as a consequence of massive gastrointestinal bleeding due to ruptured esophageal varices. The necropsy and final microbiologic analyses disclosed infection by Penicillium sp. There are thousands of fungal species of the Penicillium genera. Systemic penicilliosis is caused by the P. marneffei and was formerly a rare disease, but now is one of the most common opportunistic infection of AIDS patients in Southeast Asia. The clinical presentation usually involves the respiratory system and the skin, besides general symptoms like fever and weight loss. Penicillium spp infection caused by species other than P. marneffei normally cause only superficial or allergic disease but rare cases of invasive disease do occur. We report the fourth case of Penicillium spp CNS infection.

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