Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient

Revista do Instituto de Medicina Tropical de São Paulo

José Vassallo²  João Carlos Coelho Filho¹  Vânia Gondin Pires Do Amaral¹ 

[1] ,State University of Campinas Faculty of Medical Sciences Department of Anatomic Pathology São Paulo ,Brazil

关键词: Histiocytic necrotizing lymphadenitis;    Kikuchi lymphadenitis;    AIDS;    HIV;   

DOI  :  10.1590/S0036-46652002000500006

来源: SciELO

【 摘 要 】

Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to an impaired immune function. The purpose of the present article is to report on one case in which KL was diagnosed in an HIV-infected patient. Histomorphology and immunophenotype were similar to previous reports, but a focus of activated CD30+ macrophages was seen, what might be due to the immunological status of the patient. EBV was not detected on the sections using the in situ hybridization technique. Although rare, the occurrence of KL in HIV-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of CD30+ cells.

【 授权许可】

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