Is CK-MB isoenzyme useful for diagnosis of cardiac involvement in icteric leptospirosis?

Revista do Instituto de Medicina Tropical de São Paulo

Elizabeth Stankiewicz Machado²  José Guilherme De Faria Feres¹  Luis Augusto Feijó¹  Jarbas Andrade¹  Susie Andries Nogueira² 

[1] ,Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho Serviço de Doenças InfecciosasRio de Janeiro RJ ,Brasil

关键词: CK-MB;    Cardiac involvement;    Icteric leptospirosis;   

DOI  :  10.1590/S0036-46651995000500013

来源: SciELO

【 摘 要 】

In the absence of heart failure or cardiogenic shock, cardiac involvement diagnosis in icteric leptospirosis is possible on the basis of abnormal electrocardiograms. As metabolic and electrolytic disorders are frequently seen during acute leptospirosis infection, they may be responsible for some electrocardiograms changes. We conducted a study to assess if creatine phosphokinase isoenzyme determinations are useful in selecting patients with a high cardiac involvement suspicion. Sixty-nine patients were studied prospectively. Ten patients out of 16 with cardiac involvement and 25 without had high CK-MB levels (p>0.05), although mean values of abnormal CK-MB levels were higher in the group with cardiac involvement (p<0.05). Our analysis indicates that serum CK-MB determination does not provide a specific indicator of myocardial involvement in the course of icteric leptospirosis.

【 授权许可】

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