Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni

Revista do Instituto de Medicina Tropical de São Paulo

Sonia Maria A.f. Tonelli²  Eugênio M.a. Goulart¹  Edward Tonelli¹  Paulo Marcos Zech Coelho² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Grupo Interdepartamental de Estudos sobre EsquistossomoseBelo Horizonte MG ,Brasil

关键词: Schistosoma mansoni;    LD50;    Oxamniquine;    Praziquantel;   

DOI  :  10.1590/S0036-46651995000400014

来源: SciELO

【 摘 要 】

Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed.

【 授权许可】

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