Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha

Revista do Instituto de Medicina Tropical de São Paulo

L.c. Da Silva²  S.k. Ono¹  L.e.p. Fonseca¹  F.j. Carrilho¹  L.c.a. Mendes¹  A.v.c. França¹  C.l.a. Madruga¹  A.a. Laudanna¹ 

[1] ,Institute of Tropical Medicine School of Medicine University of São PauloSão Paulo SP ,Brazil

关键词: Chronic hepatitis;    Hepatitis C;    Antiviral Therapy;    Interferon;    Response;    Relapse;   

DOI  :  10.1590/S0036-46651995000300010

来源: SciELO

【 摘 要 】

The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this study was to describe the long term follow-up and patterns of ALT response in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha. A follow-up of 6 months or more after interferon-a was achieved in 44 patients. We have classified the serum ALT responses into six patterns and the observed frequencies were as follows: I. Long term response = 9 (20.5%); II. Normalization followed by persistent relapse after IFN = 7 (15.9%); III. Normalization with transient relapse = 5 (11.9%); IV. Temporary normalization and relapse during IFN = 4 (9.1%); V. Partial response (more than 50% of ALT decrease) = 7 (15.9%); VI. No response = 12 (27.3%). In conclusion, ALT patterns vary widely during and after IFN treatment and can be classified in at least 6 types.

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