A critical evaluation of the expression of parasitemia in experimental Chagas' disease

Revista do Instituto de Medicina Tropical de São Paulo

Roberto Sogayar²  Tereza Lieberman Kipnis¹  Paulo Roberto Curi¹ 

[1] ,UNESP Instituto de Biociências Departamento de ParasitologiaBotucatu S.P. ,Brasil

关键词: Trypanosoma cruzi;    Parasitemia;    Critical evaluation;   

DOI  :  10.1590/S0036-46651993000500002

来源: SciELO

【 摘 要 】

This paper aims to study the best way to express the parasitemia of Trypanosoma cruzi's experimentally infected animals. Individual scores may have a great variability, not emphasized by the majority of the authors. A group of 50 rats infected with 1x10(6) trypomastigotes of T. cruzi Y strain was used and the parasitemia was estimated by BRENER' s method. The results showed that the median can avoid false results due to very high or low parasitemias but it does not have the mathematic properties necessary for analysis of variance. The comparison of the means of the original and transformed data, with their respective coefficients of variability (CV), showed that the logarithmic mean (Mlog) have the minor value of CV. Therefore, the Mlog is the best way to express the parasitemia when the data show great variability. The number of the animal for group did not affect the variability of data when the Mlog and CV were used.

【 授权许可】

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