Immunopathologic studies in myocardial biopsies of patients with Chagas' disease and idiopathic cardiomyopathy

Revista do Instituto de Medicina Tropical de São Paulo

Maria De Lourdes Higuchi¹  Edgard Augusto Lopes¹  Luis Balthazar Saldanha¹  Antonio Carlos Pereira Barretto¹  Noedir A. G. Stolf¹  Giovanni Bellotti¹  Fulvio Pileggi¹ 

[1] ,São Paulo University School of Medicine Heart Institute of Clinical Hospital

关键词: Chagas' disease;    myocardial biopsy;    idiopathic cardiomyopathy;    immunopathology;   

DOI  :  10.1590/S0036-46651986000200004

来源: SciELO

【 摘 要 】

Right ventricular endomyocardial biopsies were studied in 30 patients, 15 with myocardiopathy from chronic Chagas'disease and 15 with idiopathic congestive myocardiopathy; five other myocardial samples were taken at necropsies of patients with chronic Chagas' disease. The authors tried to establish by means of direct immunofluorescence techniques whether there were immunoglobulins G, A and M, fibrinogen and C3 complement deposition in the myocardium; only one of these 30 patients exhibited a positive reaction to IgG, it was a patient with idiopathic congestive myocardiopathy. All fragments from patients with Chagas' disease showed no response to any of the fluorescent conjugates. These findings do not support the idea that anti-myoeardial antibodies have pathogenic importance in the evolution of dilated or chagasic myocardiopathies.

【 授权许可】

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