Pertussis booster vaccine for adolescents and young adults in São Paulo, Brazil

Revista de Saúde Pública

Angela Carvalho Freitas²  Valdir Okano¹  Júlio Cesar Rodrigues Pereira¹ 

[1] ,Universidade de São Paulo Faculdade de Saúde Pública Departamento de EpidemiologiaSão Paulo SP ,Brasil

关键词: Pertussis Vaccine;    administration & dosage;    Whooping Cough;    prevention & control;    Immunization Coverage;    Mathematical Models;    Vacina contra Coqueluche;    administração & dosagem;    Coqueluche;    prevenção & controle;    Cobertura Vacinal;    Modelos Matemáticos;    Vacuna contra la Tos Ferina;    administración & dosificación;    Tos Ferina;    prevención & control;    Cobertura Vacunal;    Modelos Matemáticos;   

DOI  :  10.1590/S0034-89102011000600008

来源: SciELO

【 摘 要 】

OBJECTIVE: To develop a model to assess different strategies of pertussis booster vaccination in the city of São Paulo. METHODS: A dynamic stationary age-dependent compartmental model with waning immunity was developed. The "Who Acquires Infection from Whom" matrix was used to modeling age-dependent transmission rates. There were tested different strategies including vaccine boosters to the current vaccination schedule and three of them were reported: (i) 35% coverage at age 12, or (ii) 70% coverage at age 12, and (iii) 35% coverage at age 12 and 70% coverage at age 20 at the same time. RESULTS: The strategy (i) achieved a 59% reduction of pertussis occurrence and a 53% reduction in infants while strategy (ii) produced 76% and 63% reduction and strategy (iii) 62% and 54%, respectively. CONCLUSION: Pertussis booster vaccination at age 12 proved to be the best strategy among those tested in this study as it achieves the highest overall reduction and the greatest impact among infants who are more susceptible to pertussis complications.

【 授权许可】

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