Seroprevalence of human parvovirus B19 in a suburban population in São Paulo, Brazil

Revista de Saúde Pública

E M M Huatuco²  E L Durigon²  F L A S Lebrun²  S D Passos¹  R E Gazeta¹  R S Azevedo Neto¹  E Massad¹ 

[1] ,Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de MicrobiologiaSão Paulo SP ,Brasil

关键词: Parvoviridae Infections;    Parvovirus B19;    Human;    Risk Groups;    Seroepidemiologic Studies;    Infecções por Parvoviridae;    Parvovirus B19 Humano;    Grupos de Risco;    Estudos Soroepidemiológicos;   

DOI  :  10.1590/S0034-89102008005000019

来源: SciELO

【 摘 要 】

OBJECTIVE: To analyze the prevalence of IgG antibodies to human parvovirus B19. METHODS: Cross-sectional study in a suburban community in São Paulo, Southeastern Brazil, between November 1990 and January 1991. Randomly selected (N=435) representative samples of sera were collected from healthy children older than 15 days old and adults up to 40 years old. IgG antibodies were detected using ELISA. RESULTS: High prevalence of IgG antibodies to B19 parvovirus was found in 87% of newborns. The prevalence of maternally derived IgG antibodies exponentially plunged up to the 19th month of age. Low prevalence of antibodies was found in the first 4 years of life, increasing up to 72% in those aged 31-40 years. It was estimated that the average age of first infection in this population is 21 ± 7 years old and the optimal age for vaccination with a hypothetical vaccine would be 1 year of age. CONCLUSIONS: Parvovirus B19 IgG antibody prevalence was high in newborns and those aged 31-40 years. The analysis by age groups showed a pattern similar to that found in previous studies, i.e., low prevalence of infection in children that increases with age.

【 授权许可】

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