A comparison of the effects of propofol and thiopental on tear production in dogs

Revista Ceres

Kelly Cristine De Sousa Pontes²  Andrea Pacheco Batista Borges¹  Renato Barros Eleotério¹  Priscila Soares Ferreira¹  Tatiana Schmitz Duarte¹ 

[1] ,Universidade Federal de Viçosa Departamento de Veterinária Viçosa MG ,Brasil

关键词: General anesthesia;    surgery;    dogs;    veterinary ophthalmology;    tear film production;    Anestesia geral;    cirurgia;    cães;    oftalmologia veterinária;    produção de filme lacrimal;   

DOI  :  10.1590/S0034-737X2010000600009

来源: SciELO

【 摘 要 】

The tear film plays an important role in maintaining the integrity of the ocular suface. During general anesthesia, tear production is considerably reduced, which requires care to prevent adverse effects that result in diseases of these structures. Studies comparing the effects of induction of anaesthesia with thiopental and propofol on tear production have not been carried out yet. Because these drugs are used in veterinary medicine, we decided to evaluate the tear production in 30 dogs undergoing experimental surgery as well as routine procedures at the veterinary hospital of Federal University of Viçosa. Patients were divided into two groups of equal number. All animals were sedated with clorpromazine and maintained with isoflurane in diluted oxygen. Group 1 was induced with thiopental whereas group 2 with propofol. Schirmer tear test 1 was performed before sedation (T0), 15 minutes after sedation (T1) and 10 minutes after induction of anesthesia (T2) with the drug chosen for one of the groups. There was a significant decrease in tear production for both drugs, but no significant statistical differences were found between them. Thus, considering the results and the way in which the study was conducted, we suggest protecting the cornea and conjunctiva of patients during anesthesia using any of the drugs here evaluated.

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