Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus

Arquivos de Neuro-Psiquiatria

Bruno Lopes Dos Santos-lobato¹  Elaine Aparecida Del-bel¹  José Eymard Homem Pittella¹  Vitor Tumas¹ 

关键词: nitric oxide;    basal ganglia;    striatum;    subthalamic nucleus;    aging;    óxido nítrico;    núcleos da base;    estriado;    núcleo subtalâmico;    envelhecimento;   

DOI  :  10.1590/0004-282X20150097

来源: SciELO

【 摘 要 】

Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.

【 授权许可】

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