A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD)

Arquivos de Neuro-Psiquiatria

Francisco De Assis Aquino Gondim¹  Gisele Ramos De Oliveira¹  Benedito Cadorno V. Teles¹  Marcellus H.l.p. Souza¹  Lucia L.b.c. Braga¹  Erick L. Messias¹ 

关键词: Chron's disease;    inflammatory bowel disease;    peripheral neuropathy;    small fiber neuropathy;    ulcerative colitis;    doença de Crohn;    doença inflamatória intestinal;    neuropatia periférica;    neuropatia de fibras grossas;    colite ulcerativa;   

DOI  :  10.1590/0004-282X20140223

来源: SciELO

【 摘 要 】

Neurological diseases are common in inflammatory bowel disease (IBD) patients, but their exact prevalence is unknown. Method We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD) and 70 with ulcerative colitis (UC)] and 50 controls (gastritis and dyspepsia) over 3 years. Results Our standard neurological evaluation (that included electrodiagnostic testing) revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045), 7.1 times more likely to develop any type of neuromuscular condition (p = 0.001) and 5.1 times more likely to develop autonomic complaints (p = 0.027). UC patients were 5 times more likely to develop large-fiber neuropathy (p = 0.027) and 3.1 times more likely to develop any type of neuromuscular condition (p = 0.015). Conclusion In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases than patients with gastritis and dyspepsia.

【 授权许可】

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