Arquivos de Neuro-Psiquiatria | |
Waiting time to radiotherapy as a prognostic factor for glioblastoma patients in a scenario of medical disparities | |
Luiz Victor Maia Loureiro1  Lucíola De Barros Pontes1  Donato Callegaro-filho1  Ludmila De Oliveira Koch1  Eduardo Weltman1  Elivane Da Silva Victor1  Adrialdo José Santos1  Lia Raquel Rodrigues Borges1  Roberto Araújo Segreto1  Suzana Maria Fleury Malheiros1  | |
关键词: glioblastoma; radiotherapy; waiting time; delay; prognosis; survival; glioblastoma; radioterapia; tempo de espera; atraso; prognóstico; sobrevida; | |
DOI : 10.1590/0004-282X20140202 | |
来源: SciELO | |
【 摘 要 】
Objective To evaluate the effect of waiting time (WT) to radiotherapy (RT) on overall survival (OS) of glioblastoma (GBM) patients as a reliable prognostic variable in Brazil, a scenario of medical disparities. Method Retrospective study of 115 GBM patients from two different health-care institutions (one public and one private) in Brazil who underwent post-operative RT. Results Median WT to RT was 6 weeks (range, 1.3-17.6). The median OS for WT ≤ 6 weeks was 13.5 months (95%CI , 9.1-17.9) and for WT > 6 weeks was 14.2 months (95%CI, 11.2-17.2) (HR 1.165, 95%CI 0.770-1.762; p = 0.470). In the multivariate analysis, the variables associated with survival were KPS (p < 0.001), extent of resection (p = 0.009) and the adjuvant treatment (p = 0.001). The KPS interacted with WT to RT (HR 0.128, 95%CI 0.034-0.476; p = 0.002), showing that the benefit of KPS on OS depends on the WT to RT. Conclusion No prognostic impact of WT to RT could be detected on the OS. Although there are no data to ensure that delays to RT are tolerable, we may reassure patients that the time-length to initiate treatment does not seem to influence the control of the disease, particularly in face of other prognostic factors.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202103040011864ZK.pdf | 198KB | download |