Cognition in a multiple system atrophy series of cases from Argentina

Arquivos de Neuro-Psiquiatria

Emilia Gatto¹  Ignacio Demey¹  Ana Sanguinetti¹  Virginia Parisi¹  José Luis Etcheverry¹  Galeno Rojas¹  Gregor K. Wenning¹ 

关键词: parkinsonism;    multiple system atrophy;    cognition;    parkinsonismo;    atrofia de múltiplos sistemas;    cognição;   

DOI  :  10.1590/0004-282X20140127

来源: SciELO

【 摘 要 】

Cognitive dysfunction may occur in 17-40% of patients with multiple system atrophy (MSA). It has been suggested a milder cognitive impairment in cerebellar (MSA-C) than in parkinsonian variant (MSA-P). However, differences in cognitive profiles remain under discussion.Objective To evaluate cognitive features in a series of patients with “probable MSA” from Argentina. Method After informed consent was obtained, an extensive cognitive tests battery was administered. Nine patients (6 MSA-P and 3 MSA-C) composed the sample. Results Depression was detected in 43% of patients. Seven patients showed at least one cognitive domain impairment. Temporospatial orientation, visuospatial abilities, executive and attentional functions, episodic memory and language were compromised in MSA-P, while MSA-C dysfunction was restricted to attentional and executive domains. Conclusion Despite the small sample size, our findings could suggest a more widespread cognitive impairment in MSA-P than MSA-C.

【 授权许可】

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