Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD

Arquivos de Neuro-Psiquiatria

Narahyana Bom De Araujo¹  Helena Sales Moraes¹  Heitor Silveira¹  Cynthia Arcoverde¹  Paulo Eduardo Vasques¹  Maria Lage Barca¹  Anne-brita Knapskog¹  Knut Engedal¹  Evandro Silva Freire Coutinho¹  Andrea Camaz Deslandes¹  Jerson Laks¹ 

关键词: Alzheimer?s disease;    depression;    neuropsychological tests and cognition;    doença de Alzheimer;    depressão;    testes neuropsicológicos e cognição;   

DOI  :  10.1590/0004-282X20140108

来源: SciELO

【 摘 要 】

Objective To assess cognition in major depressed (MD), Alzheimer's disease (AD), and depression in AD elderly. Method Subjects were evaluated by Mini Mental, Rey Auditory Verbal Learning Test, Rey Complex Figure, Digit Span, Similarities, Trail Making A/B, Verbal Fluency and Stroop. One-way ANOVA and multivariate models were used to compare the performance of each group on neuropsychological tests. Results We evaluated 212 subjects. Compared to MD, attention, working memory, processing speed and recall showed significantly better in controls. Controls showed significantly higher performance in all cognitive measures, except in attention compared to AD. Verbal fluency, memory, processing speed and abstract reasoning in MD was significantly higher compared to AD. AD was significantly better in general cognitive state than depression in AD. All other cognitive domains were similar. Conclusion A decreasing gradient in cognition appeared from the control to depression in AD, with MD and AD in an intermediate position.

【 授权许可】

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