Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients

Arquivos de Neuro-Psiquiatria

Marcia Da Silva Lopes¹  Ailton De Souza Melo¹  Ana Caline Nóbrega¹ 

关键词: P300 component;    idiopathic Parkinson's disease;    aging;    auditory event-related potentials;    P300;    doença de Parkinson idiopática;    envelhecimento;    potenciais evocados auditivos relacionados a eventos;   

DOI  :  10.1590/0004-282X20140005

来源: SciELO

【 摘 要 】

Electrophysiological methods could provide important information about the neurophysiological status in Parkinson's disease (PD).Objective:To investigate the prolonged auditory P300 latency in PD and its association with the disease clinical stage. Method:Clinical profiles of 44 patients were evaluated and those in initial and advanced stages of PD were identified. The frequency of altered latencies, median of latencies in each stage, and correlation between latencies and motor and non-motor clinical features were analyzed. Latencies were considered altered when they were more than two standard deviations from the mean of controls, per age group. Results:It was verified 10% of alterations in initial stages and 31% in advanced. There was correlation between latencies and non-motor clinical features. Subjects older than 65, in advanced stages, presented a significant increase of latencies. Conclusion:There was an association between PD severity and P300 prolonged latencies among subjects 65 years old or older.

【 授权许可】

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