White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive impairment

Arquivos de Neuro-Psiquiatria

Felipe Kenji Sudo¹  Carlos Eduardo Oliveira Alves¹  Gilberto Sousa Alves¹  Letice Ericeira-valente¹  Chan Tiel¹  Denise Madeira Moreira¹  Jerson Laks¹  Eliasz Engelhardt¹ 

关键词: mild cognitive impairment;    dementia;    vascular;    executive function;    neuropsychology;    neuroimaging;    cerebrovascular disorders;    comprometimento cognitivo leve;    demência vascular;    função executiva;    neuropsicologia;    neuroimagem;    transtornos cerebrovasculares;   

DOI  :  10.1590/0004-282X20130057

来源: SciELO

【 摘 要 】

Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to normal controls (NC, n=11) and correlated with Fazekas scale.ResultsVaMCI performed significantly worse than NC in Trail-Making Test (TMT) B, errors in TMT B, difference TMT B-A and Cambridge Cognitive Examination (CAMCOG) final scores. Correlations were found among scores in modified Fazekas scale and performances in TMT B (time to complete and errors), difference TMT B-A and CAMCOG total score.ConclusionExtension of white matter hyperintensities might be correlated to poorer global cognition and impairments in a set of fronto-executive functions, such as cognitive speed, set shifting and inhibitory control in VaMCI.

【 授权许可】

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