Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy

Arquivos de Neuro-Psiquiatria

Luís Otávio Sales Ferreira Caboclo²  Rafael Scarpa Neves²  Anaclara Prada Jardim²  Ana Paula Andrade Hamad²  Ricardo Silva Centeno²  Carmen Lucia Penteado Lancellotti¹  Carla Alessandra Scorza¹  Esper Abrão Cavalheiro¹  Elza Márcia Targas Yacubian²  Américo Ceiki Sakamoto¹ 

[1] ,Universidade Federal de São Paulo Department of Neurology and Neurosurgery São Paulo SP ,Brazil

关键词: epilepsy;    temporal lobe;    mesial temporal sclerosis;    pathology;    surgical;    epilepsia do lobo temporal;    esclerose mesial temporal;    patologia cirúrgica;   

DOI  :  10.1590/S0004-282X2012001200009

来源: SciELO

【 摘 要 】

Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations.

【 授权许可】

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