Clinical response to interferon beta and glatiramer acetate in multiple sclerosis patients: a Brazilian cohort

Arquivos de Neuro-Psiquiatria

Valéria Coelho Santa Rita Pereira²  Fabíola Rachid Malfetano¹  Isabella D'andrea Meira¹  Letícia Fêzer De Souza¹  Assuncion Martinez Liem¹  Angelo Maiolino¹  Soniza Vieira Alves-leon² 

[1] ,Universidade Federal do Estado do Rio de JaneiroRio de Janeiro RJ ,Brazil

关键词: multiple sclerosis;    interferon-beta;    glatiramer acetate;    therapeutics;    esclerose múltipla;    interferon beta;    acetato de glatiramer;    terapêutica;   

DOI  :  10.1590/S0004-282X2012001000005

来源: SciELO

【 摘 要 】

INTRODUCTION: Many patients with multiple sclerosis (MS) are currently receiving treatment with interferon beta (IFNb) and glatiramer acetate (GA). Identifying nonresponders patients is important to define therapy strategies. Several criteria for treatment response to IFNb and GA have been proposed. OBJECTIVE: It was to investigate the response to treatment with IFNb-1a, IFNb-1b and GA among relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: We analyzed treatment response to IFNb and GA in ninety-one RRMS patients followed for at least one year. Clinical response was established by clinical criteria based on relapses, disability progression or both. RESULTS: We observed a proportion of nonresponders, ranging from 3.3 to 42.9%, depending on the stringency of the criteria used. CONCLUSIONS: Our sample of Brazilian patients with MS has similarities when compared to other studies and there was no statistically significant difference regarding age, gender, ethnicity or disease duration between responders and nonresponders.

【 授权许可】

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