Brain atrophy at onset and physical disability in multiple sclerosis

Arquivos de Neuro-Psiquiatria

Juan Ignacio Rojas²  Liliana Patrucco²  Cristina Besada¹  Laura Bengolea¹  Edgardo Cristiano² 

[1] ,Hospital Italiano de Buenos Aires Neurology Department ,Argentina

关键词: multiple sclerosis;    brain atrophy;    Expanded Disability Status Scale;    esclerosis múltiple;    atrofia cerebral;    Expanded Disability Status Scale;   

DOI  :  10.1590/S0004-282X2012001000003

来源: SciELO

【 摘 要 】

The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.

【 授权许可】

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