Experimental encephalitis caused by Taenia crassiceps cysticerci in mice

Arquivos de Neuro-Psiquiatria

Hidelberto Matos-silva²  Bruno Pereira Reciputti²  Élbio Cândido De Paula¹  André Luiz Oliveira²  Vânia Beatriz Lopes Moura²  Marina Clare Vinaud²  Milton Adriano Pelli Oliveira²  Ruy De Souza Lino-júnior² 

[1] ,Universidade Federal de Goiás Instituto de Patologia Tropical e Saúde Pública Goiânia GO ,Brazil

关键词: neurocysticercosis;    Taenia crassiceps;    BALB/c;    C57BL/6;    neurocisticercose;    Taenia crassiceps;    BALB/c;    C57BL/6;   

DOI  :  10.1590/S0004-282X2012005000010

来源: SciELO

【 摘 要 】

OBJECTIVES: To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship. METHODS: The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory lesions. RESULTS: Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity, inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on provoking early necrosis in the cysticerci, which showed a chronic inflammation pattern. CONCLUSIONS: This experimental model induced NCC on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting inflammatory lesions with lower intensity.

【 授权许可】

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