Selective therapeutic hypothermia: A review of invasive and noninvasive techniques

Arquivos de Neuro-Psiquiatria

David Straus²  Vinay Prasad¹  Lorenzo Munoz² 

[1] ,Rush University Medical Center Department of Neurological SurgeryChicago IL ,USA

关键词: therapeutic hypothermia;    selective brain cooling;    neuroprotection;    isolated cerebral hypothermia;    hipotermia terapêutica;    resfriamento cerebral seletivo;    neuroproteção;    hipotermia cerebral isolada;   

DOI  :  10.1590/S0004-282X2011000700025

来源: SciELO

【 摘 要 】

OBJECTIVE: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. METHOD: Literature review. RESULTS: Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. CONCLUSION: Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed.

【 授权许可】

CC BY   
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