Behavioral investigation of mice with experimental autoimmune encephalomyelitis

Arquivos de Neuro-Psiquiatria

David Henrique Rodrigues¹  Márcia De Carvalho Vilela¹  Norinne Lacerda-queiroz¹  Aline Silva De Miranda¹  Larissa Fonseca Da Cunha Sousa¹  Helton José Dos Reis¹  Antônio Lúcio Teixeira¹ 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Laboratório de ImunofarmacologiaBelo Horizonte MG ,Brazil

关键词: multiple sclerosis;    experimental autoimune encephalomyelitis;    behavior;    memory;    anxiety;    esclerose múltipla;    encefalomielite autoimune experimental;    compor-tamento;    memória;    ansiedade;   

DOI  :  10.1590/S0004-282X2011000700018

来源: SciELO

【 摘 要 】

Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent.

【 授权许可】

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