Is West Nile virus a potential cause of central nervous system infection in Brazil?

Arquivos de Neuro-Psiquiatria

Cristiane N Soares²  Mauro J. Cabral Castro¹  José M Peralta¹  Marcos R.g. De Freitas²  Marzia Puccioni-sohler² 

[1] ,Fluminense Federal University Antônio Pedro Hospital Neurology Service,Brazil

关键词: viral;    meningitis;    encephalitis;    dengue infection;    West Nile virus;    CSF;    viral;    meningite;    encefalite;    dengue;    vírus do Oeste do Nilo;    líquido cefalorraquidiano;   

DOI  :  10.1590/S0004-282X2010000500016

来源: SciELO

【 摘 要 】

Meningitis and encephalitis are complications of West Nile virus (WNV) infection. Although WNV is endemic in North America, the virus has recently been reported in Colombia and Argentina. Investigation of WNV in Brazil is important since this virus has never been studied previously in this country. OBJECTIVE: To investigate the presence of WNV infection in viral encephalitis/meningitis cases of unknown etiology in the city of Rio de Janeiro, Brazil. METHOD: Thirty-seven adults with viral meningitis/encephalitis had their serum and CSF tested for WNV antibodies using the ELISA method. RESULTS: Only one case was WNV-positive, but this case was also positive for dengue. The plaque reduction neutralization test distinguished infections, and was negative for WNV. CONCLUSION: WNV can be confused with dengue infection. Their symptoms and neurological picture are similar. We did not find WNV in any patients with encephalitis and meningitis in the city of Rio de Janeiro. Up to now, it has not been detected in Brazil

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