Comparison of motor strength and function in patients with Duchenne muscular dystrophy with or without steroid therapy

Arquivos de Neuro-Psiquiatria

Samara Lamounier Santana Parreira¹  Maria Bernadete Dutra Resende¹  Edmar Zanoteli¹  Mary Souza Carvalho¹  Suely Kazue Marie¹  Umbertina Conti Reed¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Department of NeurologySão Paulo SP ,Brazil

关键词: Duchenne muscular dystrophy;    steroids;    muscle strength;    motor ability;    MRC scale;    Hammersmith motor ability score;    distrofia muscular de Duchenne;    corticoterapia;    força muscular;    habilidade motora;    escala Medical Research Council (MRC);    Hammersmith motor ability score;   

DOI  :  10.1590/S0004-282X2010000500002

来源: SciELO

【 摘 要 】

OBJECTIVE: To compare muscle strength (MS) and motor function in patients with Duchenne muscular dystrophy (DMD) receiving steroids for different times against the natural evolution of DMD described by Scott et al. METHOD: 90 patients with DMD (aged 5- 12 years), receiving steroids for one to seven years, were evaluated by Medical Research Council Scale (MRC) and Hammersmith motor ability score. The relation between MS and motor abilities measurement from our data and Scott's ones were ascertained statistically. RESULTS: The relation between patient's age and Hammersmith scores revealed decrease of 0.76 point per year for age against decrease of 2.23 points on Scott's study. The relation between MRC scale and patient's age showed decrease of 0.80 point per year of age against decrease of 3.65 points on Scott's study. CONCLUSION: In patients with DMD aged five to 12 years the progression of the disease is delayed by steroids and the motor function is less reduced than muscular strength.

【 授权许可】

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