Morphometry MRI in the differential diagnosis of parkinsonian syndromes

Arquivos de Neuro-Psiquiatria

Rômulo L Gama¹  Daniel F.g Távora¹  Rodrigo C Bomfim¹  Cruiff E Silva²  Veralice M. De Bruin²  Pedro F. De Bruin² 

[1] ,Sarah Network of Hospitals for Rehabilitation Department of Radiology Fortaleza CE ,Brazil

关键词: Parkinson;    multiple system atrophy;    progressive supranuclear palsy;    magnetic resonance imaging;    pons;    midbrain;    doença de Parkinson;    atrofia de múltiplos sistemas;    paralisia supranuclear progressiva;    ressonância magnética;    ponte;    mesencéfalo;   

DOI  :  10.1590/S0004-282X2010000300001

来源: SciELO

【 摘 要 】

This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm² and SCP smaller than 3 mmwere the most predictive measures of PSP (sensitivity 95.0 and 80.0%, respectively). For the group of MSA-c patients, Apn area below 315 mm² showed good specificity and positive predictive value (93.8% and 72.7%, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License