Modification in body weight associated with antiepileptic drugs

Arquivos de Neuro-Psiquiatria

Camilla N. De Gaspari¹  Carlos A.m. Guerreiro¹ 

[1] ,University of Campinas Department of Neurology

关键词: epilepsy;    antiepileptic drugs;    dietary habits;    body weight;    epilepsia;    drogas antiepiléticas;    hábito alimentar;    ganho de peso;   

DOI  :  10.1590/S0004-282X2010000200024

来源: SciELO

【 摘 要 】

Antiepileptic drugs (AED) may cause body weight changes. OBJECTIVE: To evaluate the dietary habits and body weight associated with AED in epileptic patients. METHOD: Sixty-six patients were subjected to two interviews, and had their weight and body mass index calculated and compared at both times, interval between six to eight months. RESULTS: It was observed that 59.1% showed weight gain. The patients who had no weight gain had a greater proportion of individuals who engaged in some form of physical activity. However, of the 45 patients who maintained their initial dietary and medication pattern, 75.6% recorded a weight gain. Weight gain was seen in 66.7% of patients on carbamazepine (n=18), 60% on valproate (n=5), 50% on carbamazepine+clobazam treatment (n=14), and 58.3% of patients on other(s) polytherapy (n=12). CONCLUSION: The patient should be alerted to possible weight gain, and should be advised about dieting and participating in regular physical activity.

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