Working memory impairment in multiple sclerosis relapsing-remitting patients with episodic memory deficits

Arquivos de Neuro-Psiquiatria

Simone Freitas Fuso²  Dagoberto Callegaro¹  Sabine Pompéia¹  Orlando F.a. Bueno¹ 

[1] ,Federal University of São Paulo Department of Psychobiology São Paulo SP ,Brazil

关键词: memory;    multiple sclerosis;    memory short-term;    neuropsychological tests;    cognition;    memória;    esclerose múltipla;    memória de curto-prazo;    testes neuropsicológicos;    cognição;   

DOI  :  10.1590/S0004-282X2010000200010

来源: SciELO

【 摘 要 】

Episodic memory is impaired in multiple sclerosis (MS) patients, possibly because of deficits in working memory (WM) functioning. If so, WM alterations should necessarily be found in patients with episodic memory deficits, but this has not yet been demonstrated. In this study we aimed at determining whether episodic memory deficits in relapsing-remitting MS are found in conjunction with impaired WM. We evaluated 32 MS patients and 32 matched healthy controls. Nineteen of the 32 patients had episodic memory impairment, and as a group only these individuals showed deficits in WM capacity, which may lead to difficulty in encoding, and/or retrieving information from episodic memory.

【 授权许可】

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