May the best friend be an enemy if not recognized early: possible role of omega-3 against cardiovascular abnormalities due antipsychotics in the treatment of autism

Arquivos de Neuro-Psiquiatria

Roberta M. Cysneiros²  Vera C. Terra¹  Hélio R. Machado¹  Ricardo M. Arida¹  José Salomão Schwartzman²  Esper A. Cavalheiro¹  Fulvio A. Scorza¹ 

[1] ,Universidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da Saúde Distúrbios do DesenvolvimentoSão Paulo SP ,Brasil

关键词: autism spectrum disorders;    heart;    sudden death;    omega-3;    desordens do espectro autista;    coração;    morte súbita;    ômega 3;   

DOI  :  10.1590/S0004-282X2009000500031

来源: SciELO

【 摘 要 】

Autism spectrum disorders (ASD) are neurodevelopment disorders that cause severe and pervasive impairment in socialization, communication, and behavior. Although the availability of antipsychotic treatment in ASD has expanded, we will be very careful with side effects of these pharmacological agents. Following this reasoning, emerging data indicate that some antipsychotics may be associated with cardiovascular adverse events (e.g., QT interval prolongation), suggesting that this could be correlated to sudden death. Quite interesting, substantial evidence from epidemiological and case-control studies indicates that omega-3 reduces the risk of cardiovascular mortality, particularly sudden cardiac death. In accordance to the above mentioned findings, as omega-3 fatty acids per se have a direct cardiovascular protective role, our paper hypothesized that omega-3 fatty acids supplementation in ASD patients treated with atypical antipsychotic drugs may reduce cardiac arrhythmias and hence sudden cardiac death.

【 授权许可】

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