Chlamydia pneumoniae and stroke: is there a direct relationship?

Arquivos de Neuro-Psiquiatria

Rubens J. Gagliardi¹  Helio H. Caiaffa-filho¹ 

[1] ,Santa Casa de São Paulo Faculty of Medical Sciences São Paulo SP ,Brazil

关键词: stroke;    chlamydia;    atherosclerosis;    risk factors;    cerebral infarct;    acidente cerebral vascular;    aterosclerose;    fatores de risco;    infarto cerebral;    chlamydia;   

DOI  :  10.1590/S0004-282X2009000400005

来源: SciELO

【 摘 要 】

OBJECTIVE: To investigate the possible relationship between atherothrombotic stroke and Chlamydia pneumoniae. METHOD: 150 patients with carotid atherothrombosis were enrolled. The casuistic was divided in three groups: ischemic stroke (IS): 65 patients; transient ischemic attack (TIA): 26 patients; and control: 59. The IS or TIA onset was up to 30 days from the beginning of the study. Carotid atheromatoses was diagnosed by Doppler-ultrasonography. Patients with cardioembolic risk or non-atherothrombotic origin were excluded. Comparisons were done between the three groups, and within each group according to the different age sub-groups, to the main arteries affected, and to the atherogenic risk factors. Bacteria detection was done using polimerase chain reaction. RESULTS: Only one patient tested positive for C. pneumoniae belonging to the control group. CONCLUSION: These results do not suggest that C. pneumoniae participated in the onset of IS or TIA or that it has a role in carotid plaque destabilization.

【 授权许可】

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