Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

Arquivos de Neuro-Psiquiatria

Teresa Cristina Bomfim De Jesus Deiró¹  Judelita Carvalho¹  Elizabeth Do Nascimento²  Jaiza Maria Barreto Medeiros¹  Fabiana Cajuhi²  Kelli Nogueira Ferraz-pereira²  Raul Manhães-de-castro² 

[1] ,Universidade Federal de Pernambuco Centro de Ciências da Saúde Departamento de NutriçãoRecife PE ,Brasil

关键词: serotonin;    programming;    SSRI;    citalopram;    reflex development;    serotonina;    programação;    ISRS;    citalopram;    desenvolvimento reflexo;   

DOI  :  10.1590/S0004-282X2008000500025

来源: SciELO

【 摘 要 】

Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats.

【 授权许可】

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