Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration

Arquivos de Neuro-Psiquiatria

Sérgio Monteiro De Almeida¹  Dione Sosnitzki Da Cunha¹  Edna Yamada¹  Elvira Missako Doi¹  Margaret Ono¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Clinical Pathology LaboratoryCuritiba PR ,Brazil

关键词: cerebrospinal fluid;    ferritin;    central nervous system;    malignant cells;    CNS neoplasm;    CNS tumors;    bacterial meningitis;    líquido cefalorraquidiano;    sistema nervoso central;    células malignas;    neoplasias do SNC;    tumores do SNC;    meningites bacterianas;   

DOI  :  10.1590/S0004-282X2008000500022

来源: SciELO

【 摘 要 】

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD) in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration.

【 授权许可】

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