Anticonvulsants to treat idiopathic restless legs syndrome: systematic review

Arquivos de Neuro-Psiquiatria

Cristiane Fiquene Conti¹  Márcio Moysés De Oliveira¹  Juliana Spelta Valbuza¹  Lucila Bizari F. Prado¹  Luciane Bizari Coin De Carvalho¹  Gilmar Fernandes Do Prado¹ 

[1] ,Universidade Federal de São Paulo Department of Emergency Medicine and Evidence Based MedicineSP ,Brazil

关键词: restless legs;    anticonvulsant;    pernas inquietas;    anticonvulsivantes;   

DOI  :  10.1590/S0004-282X2008000300034

来源: SciELO

【 摘 要 】

BACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. AIM: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. METHOD: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. RESULTS: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. CONCLUSIONS: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice.

【 授权许可】

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