Experimental nodel of C6 brain tumors in athymic rats

Arquivos de Neuro-Psiquiatria

Flávio K. Miura²  Maria José Ferreira Alves¹  Mussya Cisotto Rocha¹  Roseli S. Silva¹  Sueli M. Oba-shinjo¹  M. Uno¹  C. Colin¹  M.c. Sogayar¹  Sueli K.n. Marie¹ 

[1] ,University of São Paulo Medical School Department of NeurologySão Paulo,Brazil

关键词: brain tumor;    C6 cells;    experimental model;    glioma;    tumor cerebral;    células C6;    modelo experimental;    glioma;   

DOI  :  10.1590/S0004-282X2008000200019

来源: SciELO

【 摘 要 】

Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.

【 授权许可】

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