Immunomodulator therapy migration in relapsing remitting multiple sclerosis: a study of 152 cases

Arquivos de Neuro-Psiquiatria

Sergio Semeraro Jordy¹  Charles Peter Tilbery¹  Mirella Martins Fazzito¹ 

[1] ,Santa Casa de Misericórdia de São Paulo College of Medical Science Multiple Sclerosis Attendance and Treatment CenterSão Paulo SP ,Brazil

关键词: multiple sclerosis;    treatment;    immunomodulators;    adherence;    migration;    withdrawal;    esclerose múltipla;    tratamento;    imunomoduladores;    aderência;    migração;    abandono;   

DOI  :  10.1590/S0004-282X2008000100004

来源: SciELO

【 摘 要 】

BACKGROUND: Since 1997, immunological modulators have been used for treatment of Relapsing Remitting Multiple Sclerosis (RRMS) in the Multiple Sclerosis Attendance and Treatment Center (CATEM) with significant alterations in this disease natural history. AIM: To add data on the experience of CATEM for the treatment of RRMS patients that had immunomodulators. METHOD: RRMS patients that received continuously immunomodulator drugs were evaluated on adherence, migration, withdrawal and progression rates. The patients were divided in three groups by the period of immunomodulators intake. RESULTS: There were registered in Group 1 withdrawal in 98 patients (25%) and adherence in 292 cases (74%); Group 2 interruption of therapy in 140 patients, 92 (31%) due to progression for PSMS, 14 (5%) for pregnancy, withdrawal in 34 (11%), adherence in 88%; Group 3 progression in 41 (26%), pregnancy in 3 (2%) withdrawal in 42 (27%) and adherence in 72%. The migration rate was about one third (31.57%) and the principal cause was therapeutic failure; the mean migrating time was 0.5-2.5 years in group 3. CONCLUSION: Immunomodulatory treatment for RRMS patients may have significant levels of failure and side effects; the adherence was compatible with the international literature.

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