The effects of bromazepam on the early stage of visual information processing (P100)

Arquivos de Neuro-Psiquiatria

Fernanda Puga²  Isabel Sampaio¹  Heloisa Veiga²  Camila Ferreira¹  Maurício Cagy¹  Roberto Piedade¹  Pedro Ribeiro¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Psiquiatria Laboratório de Mapeamento Cerebral e Integração Sensório-MotoraRio de Janeiro RJ ,Brazil

关键词: bromazepam;    visual evoked potential;    P100;    bromazepam;    potencial evocado visual;    P100;   

DOI  :  10.1590/S0004-282X2007000600006

来源: SciELO

【 摘 要 】

The early stages of visual information processing, involving the detection and perception of simple visual stimuli, have been demonstrated to be sensitive to psychotropic agents. The present study investigated the effects of an acute dose of bromazepam (3 mg), compared with placebo, on the P100 component of the visual evoked potential and reaction time. The sample, consisting of 14 healthy subjects (6 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Results suggest that bromazepam (3 mg) impairs the initial stage of visual information processing, as observed by an increase in P100 latency.

【 授权许可】

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