McArdle disease with rhabdomyolysis induced by rosuvastatin: case report

Arquivos de Neuro-Psiquiatria

Paulo José Lorenzoni¹  Carlos Eduardo Silvado¹  Rosana Herminia Scola¹  Mario Luvizotto¹  Lineu César Werneck¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Internal Medicine DepartmentCuritiba PR ,Brasil

关键词: McArdle disease;    toxic myopathy;    rosuvastatin;    rhabdomyolysis;    statin myopathy;    doença de McArdle;    miopatia tóxica;    rosuvastatina;    rabdomiólise;    miopatia por estatina;   

DOI  :  10.1590/S0004-282X2007000500020

来源: SciELO

【 摘 要 】

The rosuvastatin inducing rhabdomyolysis in McArdle disease (MD) has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatinekinase levels and the forearm ischemic exercise did not increased venous lactate. The muscle biopsy showed subsarcolemmal and central acummulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.

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