Arquivos de Neuro-Psiquiatria | |
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis | |
Thereza Quirico-santos2  Vijayaprakash Suppiah2  Shirley Heggarty2  Regina Caetano1  Soniza Alves-leon1  Koen Vandenbroeck2  | |
[1] ,Queen’s University Belfast School of Pharmacy Applied Genomics Research GroupBelfast,UK | |
关键词: multiple sclerosis; interleukin-4; IL-4 receptor; single nucleotide polymorphism; ethnicity; esclerose múltipla; interleucina-4; receptor IL-4R; polimorfismo (SNP); etnia; | |
DOI : 10.1590/S0004-282X2007000100005 | |
来源: SciELO | |
【 摘 要 】
This study aimed to investigate in a population of Brazilian patients with multiple sclerosis (MS) single-nucleotide polymorphisms (SNP) in the promoter region of IL4 (*33C-T) and receptor IL4R (*Q551R A-G) genes proposed to interfere with disease progression. No significant differences were observed in either of the SNPs investigated between healthy controls (n=135) and MS patients (n=129). However, the IL4+33 TT genotype was significantly (p=0.039) higher in African descendants MS (AF-MS= 9.09%) than in Caucasian MS (CA-MS= 1.35%). It was also observed a significant (p=0.016) increase for the IL4R* Q551R CC genotype in AF-MS compared to those of Caucasian ethnicity (AF-MS= 21.62%; CA-MS= 4.35%). These results suggest that IL4+33 and IL4R*Q551 polymorphisms may have a disease-promoting role of TH2 mediators in African MS descendants. Additionally neither IL4 nor IL4R genes are susceptibility factors for Brazilian MS but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202103040009886ZK.pdf | 65KB | download |