Expression of nestin and vimentin in gliomatosis cerebri

Arquivos de Neuro-Psiquiatria

Arlete Hilbig²  Lígia Maria Barbosa-coutinho¹  Nadima Toscani¹  Marlise De Castro Ribeiro¹  Bartira Silveira Campos Da Cunha¹ 

[1] ,UFRGS Fundação Faculdade Federal de Ciências Médicas de Porto Alegre Department of Morphological Sciences

关键词: gliomatosis cerebri;    nestin;    stem cell;    brain tumor;    neuropathology;    gliomatosis cerebri;    nestina;    célula-tronco;    tumor cerebral;    neuropatologia;   

DOI  :  10.1590/S0004-282X2006000500015

来源: SciELO

【 摘 要 】

Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.

【 授权许可】

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