Correlation between parameters of electrophysiological, histomorphometric and sciatic functional index evaluations after rat sciatic nerve repair

Arquivos de Neuro-Psiquiatria

Roberto Sergio Martins²  Mario Gilberto Siqueira²  Ciro Ferreira Da Silva¹  José Píndaro Pereira Plese² 

[1] ,University of São Paulo Medical School Department of Neurosurgery

关键词: nerve repair;    sciatic functional index;    rat sciatic nerve;    nerve regeneration;    nerve morphometry;    reparo do nervo;    índice funcional ciático;    nervo ciático do rato;    regeneração nervosa;    morfometria do nervo;   

DOI  :  10.1590/S0004-282X2006000500010

来源: SciELO

【 摘 要 】

The rat sciatic nerve is a well-established model for the study of recovery from peripheral nerve injuries. Traditional methods of assessing nerve regeneration after nerve injury and repair, such as electrophysiology and histomorphometry, despite widely used in neural regeneration experiments, do not necessarily correlate with return of motor and sensory functions. The aim of this experimental study is to investigate the possible correlation between several parameters of peripheral nerve regeneration after repair of sectioned sciatic nerve in Wistar rat. A two-stage approach was used to obtain 17 parameters after electrophysiological, morphometric and sciatic functional index evaluations. Pearson's correlation analysis was performed between these results. Only two positives correlations between different classes of peripheral nerve assessments were noted, between sciatic functional index and proximal nerve fiber diameter (r=0.56, p<0.01) and between sciatic functional index and distal fiber diameter (r=0.50, p<0.01). The data presented in our study demonstrates that there is a poor correlation between the sciatic functional index and outcome measures of electrophysiological and morphometric evaluations.

【 授权许可】

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