sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis

Arquivos de Neuro-Psiquiatria

Alberto Juan Dorta-contreras¹  Piotr Lewczuc²  Elena Noris-garcía¹  María Teresa Interián-morales²  María Esther Magraner Tarrau²  Bárbara Padilla-docal¹  Xiomara Escobar-pérez² 

[1] ,Laboratorio Central de Líquido CefalorraquídeoCiudad Habana,Cuba

关键词: Angiostrongylus cantonensis;    albumin;    sICAM-1;    blood-cerebrospinal fluid barrier;    eosinophils;    meningoencephalitis;    Angiostrongylus cantonensis;    albúmina;    sICAM-1;    barrera sangre;    eosinófilos;    meningoencefalitis;   

DOI  :  10.1590/S0004-282X2006000400011

来源: SciELO

【 摘 要 】

INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License