Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas

Arquivos de Neuro-Psiquiatria

Carlos Henrique A. Botelho²  Albino Verçosa De Magalhães¹  Paulo Andrade De Mello¹  Fernando C. Schmitt¹  Luiz Augusto Casulari¹ 

[1] ,Secretaria de Estado da Saúde do Distrito FederalBrasília,Brazil

关键词: pituitary adenomas;    growth hormone;    prolactin;    p53;    Ki-67;    c-erb B2;    immunohistochemistry;    adenomas hipofisários;    hormônio de crescimento;    prolactina;    p53;    Ki-67;    c-erb B2;    imuno-histoquímica;   

DOI  :  10.1590/S0004-282X2006000100013

来源: SciELO

【 摘 要 】

The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.

【 授权许可】

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