S100B protein related neonatal hypoxia

Arquivos de Neuro-Psiquiatria

Régis Osorio Martins¹  Newra Telechea Rotta²  Luiz V. Portela¹  Diogo O. Souza¹ 

[1] ,Universidade Federal do Rio Grande do SulPorto Alegre RS ,Brazil

关键词: S100B;    hypoxic-ischemic encephalopathy;    newborn;    asphyxia;    S100B;    encefalopatia hipóxico-isquêmica;    recém-nascido;    asfixia;   

DOI  :  10.1590/S0004-282X2006000100006

来源: SciELO

【 摘 要 】

Biochemical markers have played an increasingly relevant role in the assessment of neonatal asphyxia. The S100B protein is particularly important in research conducted in this field. The purpose of this study was to underline the importance of the S100B protein in the assessment of term newborn infants with hypoxic-ischemic encephalopathy, as well as to relate it to other substances also involved in the ischemic process. An assessment was made from September 2003 to October 2004 of 21 term newborn infants who developed hypoxic-ischemic encephalopathy. Samples were collected on the 1st and 4th day of life and S100B protein and lactate concentrations were calculated using the immune cytochemical method. A positive relationship was found between the two substances. Additionally, a comparison between the two substances showed a statistically significant correlation.

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