Metastatic prolactinoma: case report with immunohistochemical assessment for p53 and Ki-67 antigens

Arquivos de Neuro-Psiquiatria

Paulo S. Crusius²  Cassiano M. Forcelini²  Adroaldo B. Mallmann²  Daniela A. Silveira¹  Elder Lersch¹  Cláudio A. Seibert²  Marcelo U. Crusius²  Charles A. Carazzo²  Cassiano U. Crusius²  Eduardo Goellner² 

[1] ,Institute of Neurology and NeurosurgeryPasso Fundo RS ,Brazil

关键词: prolactinoma;    pituitary carcinoma;    metastasis;    p53;    Ki-67;    prolactinoma;    carcinoma pituitário;    metástase;    p53;    Ki-67;   

DOI  :  10.1590/S0004-282X2005000500029

来源: SciELO

【 摘 要 】

Pituitary carcinomas are rare neoplasms characterized by craniospinal and/or systemic metastases originated from the pituitary. Their histopathology is frequently indistinguishable from that of benign adenomas. The development of markers that better reflect their behavior is desirable. We present the case of a 47 year-old man with a prolactin-secreting macroadenoma who was submitted to surgeries, cranial radiation therapy, and bromocriptine treatment, but evolved to a fatal outcome after the disclosure of intracranial metastases. Tumor samples underwent p53 and Ki-67 immunohistochemical assessment. p53 was absent in all samples, a rare finding among pituitary carcinomas. Ki-67 proliferative index was 2.80% in the original tumor, 4.40% in the relapse, and 4.45% in the metastasis. The figure in the relapse is higher than the expected for a noninvasive adenoma. In conclusion, p53 staining is not positive in all pituitary carcinomas. A high Ki-67 proliferative index in a pituitary adenoma might indicate a more aggressive behavior.

【 授权许可】

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