Clonidine in respiratory panic disorder subtype

Arquivos de Neuro-Psiquiatria

Alexandre M. Valença²  Antonio E. Nardi²  Marco A. Mezzasalma²  Isabella Nascimento²  Fabiana L. Lopes²  Walter A. Zin¹  Marcio Versiani² 

[1] ,Federal University of Rio de Janeiro Institute of Psychiatry Laboratory of Panic & RespirationRio de Janeiro RJ ,Brazil

关键词: respiration;    panic attack;    norepinephrine;    panic subtypes;    anxiety disorder;    respiração;    ataque de pânico;    norepinefrina;    subtipos de pânico;    transtorno de ansiedade;   

DOI  :  10.1590/S0004-282X2004000300004

来源: SciELO

【 摘 要 】

OBJECTIVE: Clonidine, which inhibits locus coeruleus discharge, would seem for theoretical reasons to be a good antipanic drug. Panic disorder (PD) presents a heterogeneous cluster of symptoms and a classification based on subtypes has been suggested and the respiratory symptoms group appears as a distinct subtype. METHOD: We report three cases of respiratory PD patients who were successfully treated with clonidine. RESULTS: Patients obtained panic free status, reduced anxiety levels and better functioning after clonidine administration (0.30-0.45 mg/day) for 6 weeks. CONCLUSION: Clonidine can be effective in the treatment of respiratory PD. This drug might play a role in relieving symptoms of anxiety due to noradrenergic hyperactivity in these patients.

【 授权许可】

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