Ankylosing spondylitis and central core disease: case report

Arquivos de Neuro-Psiquiatria

Rosana Herminia Scola¹  Kátia Lin¹  Fábio Massaiti Iwamoto¹  Walter Oleschko Arruda¹  Lineu Cesar Werneck¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Department of Internal Medicine,Brazil

关键词: ankylosing spondylitis;    central core disease;    muscle biopsy;    espondilite anquilosante;    doença do core central;    biópsia muscular;   

DOI  :  10.1590/S0004-282X2003000400031

来源: SciELO

【 摘 要 】

Ankylosing spondylitis (AS) is an inflammatory disorder of unknown cause that primarily affects the axial skeleton. Neurological manifestations of AS are usually related to spinal deformities. Previous studies of the paraspinal muscles of AS patients showed muscle fiber atrophy, and core fibers. On the other hand, central core disease (CCD) is a genetic condition that primarily involves the skeletal muscles, but can present articular deformities secondary to muscular weakness. We report the case of a 45-year-old man with clinical and radiological diagnosis of AS and proximal muscular weakness in the lower limbs. Needle electromyography showed myopathic features and nerve conduction study was normal. Muscle biopsy disclosed almost complete predominance of type-1 fibers, and fibers with central cores. This is the first report of AS and CCD. Whether central core myopathy is coincidental or a new association with AS is discussed.

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