Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats

Arquivos de Neuro-Psiquiatria

Cristiano Mendes-da-silva¹  Sandra Lopes De Souza¹  Jairza Maria Barreto-medeiros¹  Sebastião Rogério De Freitas-silva¹  Daniela Eugênia Costa Antunes¹  Allan Delano Urbano Cunha¹  Valdenilson Ribeiro Ribas¹  Maria Flávia Simões De França¹  Maria Inês Nogueira¹  Raul Manhães-de-castro² 

[1],Universidade de Paris VI

关键词: depression;    serotonin;    selective serotonin reuptake inhibitor;    neurogenesis;    depressão;    serotonina;    inibidor de recaptação da 5-HT;    neurogênese;   

DOI  :  10.1590/S0004-282X2002000600008

来源: SciELO

【 摘 要 】

Serotonin plays a role at the pathophysiology of depression in humans and in experimental models. The present study investigated the depressive behavior and the weigh evolution in adult rats (60 days) treated from the 1st to the 21st postnatal day with fluoxetine, a selective serotonin reuptake inhibitor (10 mg/kg, sc, daily). The depressive behavior was induced by the forced swim test (FST). The animals were submitted to two sessions of FST: 1st session for 15 min and the 2nd session 24h later, for 5 min. During the 2nd session the Latency of the Attempt of Escape (LAE) and Behavioral Immobility (BI) were appraised. The Fluoxetine group when compared to the Control group, showed an increase in LAE and a decrease in BI. The neonatal administration of fluoxetine reduced the depressive behavior in adult rats, possibly by increase in the brain serotonergic activity. This alteration can be associated to process of neuroadaptation.

【 授权许可】

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