Morphoquantitative effects of acute diabetes on the myenteric neurons of the proximal colon of adult rats

Arquivos de Neuro-Psiquiatria

Maria Montserrat D.p. Furlan¹  Sônia L. Molinari¹  Marcílio H. De Miranda Neto¹ 

[1] ,Universidade Estadual de Maringá Departamento de Ciências Morfofisiológicas Maringá PR ,Brasil

关键词: acute diabetes;    myenteric neurons;    proximal colon;    diabetes agudo;    neurônios mioentéricos;    colo proximal;   

DOI  :  10.1590/S0004-282X2002000400012

来源: SciELO

【 摘 要 】

The effects of acute diabetes on the density and size of the myenteric neurons of the proximal colon of adult rats were investigated. The injection of streptozotocin was followed by a period of observation of seven days, during which the diabetic animals showed weight loss, excessive food and water intake, large urinary debt and hyperglicemia. The whole-mounts from the proximal colon were stained with the techniques of Giemsa and of the NADH-diaphorase, and the employment of these techniques made it possible to verify a decrease on the neuronal density and on the cell body size of the myenteric neurons in the colon of the diabetic rats. These observations were discussed in terms of the pathophysiology of the diabetes and the experimental protocol.

【 授权许可】

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