Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report

Arquivos de Neuro-Psiquiatria

Luís Otávio Sales Ferreira Caboclo²  Nancy Huang²  Guilherme Alves Lepski²  José Antônio Livramento¹  Carlos Alberto Buchpiguel¹  Cláudia Sellitto Porto²  Ricardo Nitrini² 

[1] ,University of São Paulo Medical School Department of NeurologySão Paulo SP ,Brazil

关键词: Creutzfeldt- Jakob disease;    iatrogenic form;    growth hormone;    diffusion MRI;    CSF 14-3-3 protein;    doença de Creutzfeldt-Jakob;    forma iatrogênica;    hormônio de crescimento;    ressonância magnética com difusão;    proteína 14-3-3 no LCR;   

DOI  :  10.1590/S0004-282X2002000300022

来源: SciELO

【 摘 要 】

We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.

【 授权许可】

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