Arquivos de Neuro-Psiquiatria | |
Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report | |
Luís Otávio Sales Ferreira Caboclo2  Nancy Huang2  Guilherme Alves Lepski2  José Antônio Livramento1  Carlos Alberto Buchpiguel1  Cláudia Sellitto Porto2  Ricardo Nitrini2  | |
[1] ,University of São Paulo Medical School Department of NeurologySão Paulo SP ,Brazil | |
关键词: Creutzfeldt- Jakob disease; iatrogenic form; growth hormone; diffusion MRI; CSF 14-3-3 protein; doença de Creutzfeldt-Jakob; forma iatrogênica; hormônio de crescimento; ressonância magnética com difusão; proteína 14-3-3 no LCR; | |
DOI : 10.1590/S0004-282X2002000300022 | |
来源: SciELO | |
【 摘 要 】
We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.
【 授权许可】
CC BY
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