Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats

Arquivos de Neuro-Psiquiatria

Débora De Mello Gonçales Sant'ana²  Sônia Lucy Molinari¹  Marcílio Hubner Miranda-neto¹ 

[1] ,Universidade Estadual de MaringáMaringá PR ,Brazil

关键词: enteric neurons;    proteic desnutrition;    ascending colon;    hematology;    vitamin B;    neurônios entéricos;    desnutrição protéica;    colo ascendente;    hematologia;    vitamina B;   

DOI  :  10.1590/S0004-282X2001000400003

来源: SciELO

【 摘 要 】

The aims of this work were to evaluate the effects of the deficient ingestion of protein and vitamin B on the biochemical and hematologic parameters and on the NADH- and NADPH-diaphorase positive myenteric neurons. The control animals (n=10) received commercial chow and the experimental rats (n=10) received chow with protein level reduced to 8% during 120 days. At the time of killing blood was collected for assessment of the blood and hematologic parameters and the ascending colon for quantitative analysis of the neurons of the myenteric plexus. It was observed that the reduction of the protein level to 8% coupled to the reduction of the levels of vitamin B in adult rats neither led to qualitative or quantitative changes on red or white blood cells, nor decreased globulin levels, induced the formation of edema or gave rise to clinical signs typical of protein or vitamin B deficiency. On the other hand, the experimental protocol led to less weight gain, change on the body composition with fat deposition; decrease of the values of serum total protein and albumin; reduction of the area of colon and density of nitrergic and NADH-diaphorase myenteric neurons inferior to the expected.

【 授权许可】

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